Arthrotec is a combination medication containing:

Diclofenac sodium (an NSAID that reduces inflammation and pain)
Misoprostol (a protective agent that helps prevent stomach ulcers caused by NSAIDs)

How It Works

Diclofenac reduces joint pain and swelling by blocking enzymes that cause inflammation.
Misoprostol protects the stomach lining by increasing mucus production and blood flow to reduce the risk of ulcers.

NSAIDs block COX enzymes to reduce inflammation

Misoprostol is a prostaglandin analogue that protects the stomach lining

Uses

Osteoarthritis
Rheumatoid arthritis

Particularly for patients at risk of NSAID-related stomach ulcers.

Important Warnings

Not for use during pregnancy (can cause miscarriage and birth defects)
Increased risk of heart attack, stroke, and kidney damage
Possible serious gastrointestinal bleeding and ulcers
Avoid if allergic to NSAIDs or have active stomach ulcers

Warning: Serious side effects possible

Dosage Guidelines

Usually, 1 tablet of Arthrotec 50 mg three times daily or 1 tablet of Arthrotec 75 mg twice daily.
Take with food to reduce stomach upset.
Avoid chewing or crushing tablets.