Dostinex Tablet 0.5mg

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Dostinex contains cabergoline, used to treat high prolactin levels, infertility, or stop breast milk production.
It works by stimulating dopamine receptors, which reduce prolactin secretion from the pituitary gland.
Side effects include nausea, dizziness, and low blood pressure; use only under prescription supervision.

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Feature	Description
Generic Name	Cabergoline
Brand Name	Dostinex
Strength	Typically 0.5 mg tablet; dosing ranges from 0.25–2 mg per week depending on indication
Drug Class	Dopamine D₂ receptor agonist (ergot-derived)
Mechanism of Action	Suppresses prolactin secretion by activating dopamine receptors in the pituitary gland
Indications	Hyperprolactinemia (amenorrhea, infertility, prolactinomas), suppression of lactation, and off-label uses
Dosage	Standard: 0.25 mg twice weekly, increasing by 0.25 mg every 4 weeks up to 1 mg twice weekly; lactation suppression regimens differ
Onset/Duration	Plasma half-life ~80 hours; long-lasting prolactin suppression
Common Side Effects	Nausea, headache, dizziness, fatigue, constipation, abdominal discomfort
Serious Risks	Orthostatic hypotension, cardiac valvulopathy, fibrosis (heart, lungs, abdomen), impulse control disorders
Precautions	Baseline and periodic echocardiograms for valvular disease; avoid use in uncontrolled hypertension or existing fibrosis
Contraindications	Hypersensitivity to ergot derivatives, uncontrolled hypertension, valvular heart disease, fibrotic conditions
Drug Interactions	Avoid dopamine antagonists (e.g., metoclopramide), CYP3A4 inhibitors (e.g., ketoconazole), ergot derivatives
Pregnancy & Lactation	Use with caution – may suppress milk production; not recommended postpartum unless necessary
Storage	Store at 20–25 °C in original container; protect from moisture and heat
Prescription Status	Prescription-only; use under specialist supervision