Progynova 2 mg (Estradiol Valerate tablets)

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Progynova 2 mg is a prescription estrogen tablet used in hormone replacement therapy for menopause symptom relief, osteoporosis prevention, and transgender hormone regimens.
Typical dosing is 1–2 mg daily (possibly cyclic), with common side effects like breast tenderness and nausea; there are risks for blood clots, hormone-sensitive cancers, and cardiovascular events, requiring regular medical monitoring.
It must be used cautiously if you have a history of hormone-related health conditions or risk factors such as smoking.

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Name:

Progynova 2 mg (Estradiol Valerate tablets)

Category:

Hormone Replacement Therapy (HRT) / Estrogen Therapy

Prescription Status:

Prescription Only Medicine (POM)

Active Ingredient:

Estradiol valerate 2 mg (a form of estrogen)

Uses:

Relief of menopausal symptoms: hot flashes, night sweats, vaginal dryness
Prevention of osteoporosis in postmenopausal women
Part of gender-affirming hormone therapy (MtF transition)
Hormonal support in hypogonadism or ovarian failure

Dosage:

Common dosing: daily or every other day, 1–2 mg based on symptoms and serum estrogen levels
Regimens vary: daily dosage or cyclic (e.g., 2 mg for 21 days followed by 7 days break) as guided by a healthcare provider

Mechanism of Action:

Estradiol replaces estrogen lost during menopause, binding to estrogen receptors in the body and helping restore hormonal balance.

Common Side Effects:

Breast tenderness, nausea, bloating, headache
Fluid retention, abdominal cramps, mood changes
Spotting or breakthrough bleeding, especially early in therapy

Serious Risks:

Blood clots (VTE) – risk increases after 1 year or in smokers/obese individuals
Breast and endometrial cancer – particularly with unopposed estrogen
Cardiovascular issues: stroke, heart disease
Gallbladder disease
Regular monitoring of blood pressure, lipids, liver and glucose levels is recommended

Contraindications:

Not to be used in individuals with:

History of estrogen-dependent cancer (e.g., breast, endometrial)
Recent stroke or heart attack, active blood clots, or untreated hypertension
Liver disease, undiagnosed vaginal bleeding, porphyria, or known hypersensitivity to estrogen

Precautions:

Regular gynaecological and mammographic exams advised
Combine with a progestin for women with an intact uterus to reduce endometrial cancer risk
Avoid smoking while on therapy
Caution in migraine sufferers, diabetics, those with high cholesterol, or thyroid disorders