Provera 5 mg (medroxyprogesterone acetate)

Provera 5 mg (medroxyprogesterone acetate) is a prescription-only progestin used in hormonal therapy for various gynecological conditions.

Prescription Status & Category

• Prescription Only Medicine (POM)

• Category: Hormonal therapy / Progestin

Common Uses

• Treats absent or irregular menstrual periods (amenorrhea)

• Manages heavy or dysfunctional uterine bleeding

• Helps relieve endometriosis symptoms

• Prevents endometrial hyperplasia (thickening of the uterus lining) when used with estrogen in hormone replacement therapy

Typical Dosage

• 5 mg daily for 5–10 days, often starting mid-cycle

• When used alongside estrogen: 5–10 mg daily for 12–14 days each month

Common Side Effects

• Changes in bleeding patterns (spotting, breakthrough bleeding, skipped periods)

• Headache, nausea, and breast tenderness

• Bloating or mild fluid retention

• Weight fluctuations

Serious Side Effects (Seek Medical Help)

• Blood clots (e.g., deep vein thrombosis, pulmonary embolism)

• Stroke or heart attack

• Liver dysfunction

• Gallbladder disease

• Mood changes or depression

• Elevated blood pressure or blood sugar

Precautions / Contraindications

• Avoid if you have a history of blood clots, severe liver disease, or hormone-sensitive cancers

• Use caution with migraines, epilepsy, diabetes, hypertension, asthma, or depression

• Do not use during pregnancy; use non-hormonal contraception while taking Provera

• May interact with medications like rifampicin or phenytoin

Mood & User Experience

• Some users report mood swings, fatigue, anxiety, or sleepiness

• Digestive symptoms (cramps, diarrhea, or constipation) may occur in a minority