Casodex 50mg Tablet 28’s

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Casodex (bicalutamide) is an oral non-steroidal anti-androgen used primarily in the treatment of advanced prostate cancer, often in combination with LHRH analogues. It blocks androgen receptors, preventing testosterone from stimulating cancer cell growth. Common side effects include gynecomastia, hot flashes, and liver enzyme elevation.

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Category	Details
Generic Name	Bicalutamide
Brand Name	Casodex
Drug Class	Non-steroidal anti-androgen
Dosage Form	Oral tablet
Strengths Available	50 mg (most common), also 150 mg in some regions
Manufacturer	AstraZeneca (original brand); also available as generics
Indications	– Advanced prostate cancer (in combination with LHRH analogues)
	– Locally advanced prostate cancer (monotherapy in some cases)
Mechanism of Action	Competitively inhibits binding of androgens (testosterone, DHT) to receptors
	in prostate cancer cells, blocking their growth-stimulating effects
Usual Adult Dose	50 mg once daily (often with an LHRH analogue like leuprolide or goserelin)
	150 mg once daily (monotherapy, less common)
Onset of Action	Within days; full anti-androgenic effect may take weeks
Half-life	Approximately 6 days
Metabolism	Hepatic (liver); primarily via CYP3A4 enzyme
Excretion	Feces (major route), urine (minor route)
Common Side Effects	– Gynecomastia
	– Hot flashes
	– Decreased libido
	– Fatigue
	– Nausea
	– Diarrhea
Serious Adverse Effects	– Liver toxicity (monitor LFTs)
	– Interstitial lung disease (rare)
Contraindications	– Women, especially pregnant or breastfeeding women
	– Known hypersensitivity to bicalutamide
Drug Interactions	– Warfarin (may increase INR)
	– CYP3A4 substrates/inhibitors/inducers
Pregnancy Category	X (contraindicated in pregnancy)
Storage Conditions	Store at room temperature (15–30°C), away from moisture and light
Monitoring Parameters	– Liver function tests (baseline and during treatment)
	– PSA levels
	– Testosterone levels