Amoxinate 457 mg per 5 mL Suspension – Luex

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Amoxinate 457 mg/5 mL Suspension by Luex is a broad-spectrum antibiotic combining amoxicillin and clavulanic acid to treat various bacterial infections. It is taken orally after reconstitution and should be stored in a refrigerator and used within 7 to 10 days.

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Product Overview

Each 5 mL of reconstituted suspension contains

Amoxicillin 400 mg as trihydrate
Clavulanic acid 57 mg as potassium clavulanate
Totaling approximately 457 mg of combined active ingredients

Form:

Dry white to off white flavored powder
Reconstitutes into a white to tan oral suspension
Usually provided in a 70 mL bottle

Manufacturer: Luex

Indications

Amoxinate 457 mg suspension is used to treat bacterial infections such as

Dosage and Administration

Children 2 months and older under 40 kg

Usual dose ranges from 22.5 to 90 mg of amoxicillin per kg per day
Divide the total dose into two doses per day
Dosing depends on severity of infection

Adults and children over 40 kg

Typical dose is two to three times per day
Total daily dose may reach up to 1750 mg amoxicillin and 250 mg clavulanic acid

Reconstitution instructions
1 Add about two thirds of the required water to the powder
2 Shake well to dissolve
3 Add the remaining water and shake vigorously again
4 Store in a refrigerator
5 Use within 7 to 10 days

Best taken with food to reduce stomach upset and improve effectiveness

Contraindications and Precautions

Do not use if the patient is allergic to penicillin cephalosporin or clavulanic acid
Avoid in patients with past liver problems caused by similar medicines
Monitor kidney and liver function during extended treatment

Side Effects

Common side effects include

Diarrhea
Nausea and vomiting
Abdominal pain
Skin rash or itching

Rare but serious side effects include

Severe allergic reactions
Liver injury
Inflammation of the colon

Mechanism of Action

Amoxicillin kills bacteria by disrupting cell wall formation
Clavulanic acid blocks beta lactamase enzymes that make some bacteria resistant

Storage and Handling

Store the dry powder at room temperature
After mixing with water refrigerate the suspension
Shake well before each dose
Discard any unused suspension after 7 to 10 days